|
KMID : 0352519920290010285
|
|
Korea Univercity Medical Journal
1992 Volume.29 No. 1 p.285 ~ p.298
|
|
|
The Study of Growth Promoting Factors and Proliferating Cell Nuclear Antigen (PCNA) in Glial Tumors and Meningiomal of Brain
|
|
|
|
|
Abstract
|
|
|
A recent revolutionary study in molecular biology leads to understand that growth factors are necessary for normal development and the function of the cells. It has also found that many of the growth factors or their respective receptors are
related to
products of transforming viral genes and normal cellular counterparts called proto-oncogenes. The activation of protooncogenes results in growth factor secretion or growth factor receptor expression. The concommitant expression of growth factors
and of
their receptors results in autocrine growth stimulation. related to the development of human cancers.
In this study the presence of estrogen receptor (ER-D5) and epidermal growth factor receptor (EGFR). expression of c-myc protein, and the positivity of proliferating cell nuclear antigen (PCNA) were evaluated in 26 cases of low grade (13) and
high
grade
(7) astrocytomas and glioblastoma multiforme (6). and 22 cases of meningiomas. by immunohistochemical staining on paraffin sections.
@ES The results are summerized as follows:
@EN ER-D5 was positive in 9 among 22 cases of meningioma (40.9%). and in 4 among 26 cases of astrocytoma and glioblastoma multiform (19.2%).
2. EGFR was positive in 20 of 22 meningiomas (90.9%). and 20 of 26 astrocytomas and glioblastoma multiforme than in low grade tumors.
3. C-myc protein was positive in all. except one. meningiomas and all malignant astrocyomas and glioblastoma multiforme. however. it was only positive in 8 among 13 cases of low grade astrocytoma (61.5%). The positivity was higher in the
meningotheliomatous type of meningiomas than in other histologic types. and also higher in malignant astrocytomas and glioblastoma multiforme than in low grade astrocytomas.
4. The PCNA-positive cells were absent or rarely seen in one case of meningiomas ad 8 of 13 cases of low grade astrocytomas. The proportion of positive cells was higher in the meningotheliomatous type of meningiomas than in others. and higher in
malignant astrocytomas and glioblastoma multiforme than in low grade astrocytomas.
5. There was a positive correlation between the expressibility of EGFR, c-myc protein, and PCNA. The degree of positivity was higher in malignant forms of glial tumors.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|